King's College London
Molecular mechanisms of C9ORF72 repeat expansion toxicity in frontotemporal dementia
Alzheimer's Research UK
Frontotemporal dementia is the second most prevalent form of early onset dementia after Alzheimers disease. A large proportion of frontotemporal dementia cases are caused by a genetic defect that enlarges part of a gene. The aim of this project is to understand how nerve cells from frontotemporal dementia patients handle this defective gene. This knowledge will open the way to the development of treatments to slow down or, hopefully, halt the progression of disease.