Molecular Networks of Dopaminergic Neurons in Chordates (DOPAMINET)
|Dr||Stefano||Gustincich||SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI||Italy|
|Institution||SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI|
Parkinson,Zebrafish,Dopamine,System Biology,Gene Network,Transcriptome,Ciona,High Throughput,Gene Discovery,Enhancers,Cis-Regulatory Elements
Parkinson Disease is the second most common progressive neurodegenerative disorder. The selective degeneration of subsets of midbrain dopaminergic neurons is believed to be the primary cause for disruption of the ability to control movements. Objective. We propose to apply a highly interdisciplinary approach to construct complex networks consisting of protein coding genes, non-protein-coding genes and cis-regulatory elements within dopaminergic neurons in the brain across three chordate organisms (Mouse, Zebrafish and Ciona) to identify and compare gene regulatory networks in these neurons.