Title of project or programme

Nanosystems for the early Diagnosis of Neurodegenerative diseases (NADINE)

Principal Investigators of project/programme grant
Title Forname Surname Institution Country
Professor Jorg Kutter DANMARKS TEKNISKE UNIVERSITET Denmark
Address of institution of lead PI
Institution DANMARKS TEKNISKE UNIVERSITET
Street Address
City
Postcode
Country

Denmark

Source of funding information

European Commission

Total sum awarded (Euro)

9000000

Start date of award

01-09-2010

Total duration of award in months

60

The project/programme is most relevant to
  • Alzheimer’s disease and other dementias
  • Neurodegenerative disease in general
Keywords
Research abstract in English

NADINE will address this challenge of a critical need for novel reliable tools for the early, differential, potentially predictive, and minimally invasive diagnosis of neurodegenerative disorders. To be widely usable, the system should be fully integrated and highly automated. It should also identify and quantify accurately a multiplicity of molecular biomarkers, as well as non-conventional supramolecular biomarkers such as nano-aggregates. Besides its obvious applications in diagnosis, this new technology will also have applications in drug development, for follow-up of complex biomarker signatures during disease evolution, and clinical trials. The scientific and technological objectives
1. Development of innovative nanoparticles for imuno-capturing and -detection
2. Improved micro-nanofluidic technologies
3. Improved electrophoretic separations and detection sensitivity on chip at the pico- or femtomolar level
4. Development of innovative microarrays on chip
5. Development of diagnostic signature approaches based on innovative bioinformatics tools 6. Integration of multimodal protein and peptide analysis in a single, fully integrated microfluidic system
7. Development of a fully integrated prototype for the minimally invasive diagnosis for neurodegenerative diseases
8. Societal and industrial objectives towards diagnostic instruments addressing major challenges in predictive medicine, and preparing next-generation bioanalysis technologies
9. Opening the route to new classes of applications not yet covered by microfluidic systems

Lay Summary

Types: Investments > €500k
Member States: Denmark
Diseases: Alzheimer's disease & other dementias, Neurodegenerative disease in general
Years: 2011
Database Categories: N/A
Database Tags: N/A

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