National Child Development Study
UCL Institute of Education
UCL Institute of Education
Core funding from ESRC
Neurodegenerative disease in general
NCDS follows 17,000 people born in Great Britain in one week in 1958 and collects information on physical and educational development, economic circumstances, employment, family life, health, wellbeing and attitudes
NCDS is unparalleled internationally as an ongoing birth cohort of those born in the 1950s.
NORTH, T.L, PALMER, T.M, LEWIS, S.J, COOPER, R, POWER, C, PATTIE, A, STARR, J.M, DEARY, I.J, MARTIN, R.M, AIHIE SAYER, A, KUMARI, M, COOPER, C, KIVIMAKI, M, KUH, D, BEN-SHLOMO, Y and DAY, I.N. (2015) Effect of smoking on physical and cognitive capability in later life: a multicohort study using observational and genetic approaches . BMJ Open, 5(12), e008393. | GEOFFROY, M-C, HERTZMAN, C, LI, L and POWER, C. (2012) Morning salivary cortisol and cognitive function in mid-life: evidence from a population-based birth cohort. Psychological Medicine, 42(8), 1763-1773. |DREGAN, A. and GULLIFORD, M. C. (2012) Is Illicit Drug Use Harmful to Cognitive Functioning in the Midadult Years? A Cohort-based Investigation. American Journal of Epidemiology, 175(3), 218-227
The NCDS original target sample was all births in England, Scotland and Wales in one week of March 1958. In addition, in advance of the age 7, age 11 and age 16 follow-ups the sample was augmented with immigrants born within the relevant week.
More than 15,000 participants
Information from childhood sweeps: Birth circumstances, birth weight, breastfeeding, general health, child development, specific conditions, disabilities/ special needs, hospital admissions, immunisation, medication, accidents, menstruation, eating problems, exercise, smoking, drinking, behavioural problems, emotional problems, sleeping problems, medical assessments (height, weight, audiometry, speech, co-ordination, vision, pubertal development), cognitive assessments, parental health, parental smoking.| Information from adult sweeps: General health, specific conditions, disability/limitations, menopause, weight, accidents, mental health, well-being, sleep, smoking, alcohol, drug use, diet, exercise, cognition.| Information from the biomedical survey (Age 44): Near, distance and stereo vision; hearing; lung function; blood pressure and pulse, height and weight; and waist and hip circumference. Samples of blood were taken from which DNA was extracted and immortalised cell cultures created (where consent was provided), from which the cohort has been extensively genotyped. Blood samples also used to measure lipids, clotting factors, inflammatory markers, total specific serum IgE. Saliva was collected to measure levels of cortisol.
Prospective cohort| Longitudinal
At the planning stage | Data collection ongoing| Data collection ongoing| Data collection ongoing
Only through the study
Also through links to medical records and other records
Yes (participants given permission to be re-contacted via PIs)
Data summarised in database
Data is held as individual records
Apply to PI or co-ordinator at resource| Apply to PI or co-ordinator at resource| National access| International access| Resource has own ethics approval so usually no need for separate external ethics approval
Data to be made publicly available immediately
Living donors: blood| Living donors: DNA| Living donors: blood derivatives
Primary Samples: Stabilised samples (frozen or fixed)| Secondary samples:(derivatives of primary samples)| Secondary samples: plasma| Secondary samples: DNA| Secondary samples: cell lines derived from primary samples
Yes, for all the cohort