Title of project or programme

Neuro-immune modelling

Principal Investigators of project/programme grant
Title Forname Surname Institution Country
Professor Jean Manson University of Edinburgh United Kingdom
Address of institution of lead PI
Institution The Roslin Institute, University of Edinburgh
Street Address Easter Bush, Midlothian
City Edinburgh, Scotland
Postcode EH25 9RG

United Kingdom

Source of funding information

Biotechnology and Biological Sciences Research Council

Total sum awarded (Euro)


Start date of award


Total duration of award in months


The project/programme is most relevant to
  • Prion disease
Research abstract in English

The spread of TSE infection within the body of an animal often starts with transport from the site of invasion to the lymphoreticular system (LRS) and then to the central nervous system (CNS). We wish to study this process to identify the important factors that affect host susceptibility and to define control points at which neuroinvasion might be arrested so that clinical disease does not occur. The objectives of this theme are: To determine the mechanisms of TSE agent delivery to the lymphoid system. To determine crucial sites of TSE agent accumulation and/or replication in lymphoid tissues. To determine the mechanisms of neuroinvasion (how TSE agents spread to peripheral nerves). To determine the role of macrophages in TSE pathogenesis. To determine the influence of host age on TSE agent neuroinvasion. To determine the influence of inflammation on TSE pathogenesis.

Lay summary

Types: Investments > €500k
Member States: United Kingdom
Diseases: Prion disease
Years: 2011
Database Categories: N/A
Database Tags: N/A

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