Dr Prashant Bharadwaj
Neuroprotective functions of autophagy regulators in Alzheimer's disease
Alzheimer's disease & other dementias
amyloid beta-protein | autophagy | neurodegeneration | amp-activated protein kinase | protein phosphatase
The accumulation of the beta amyloid protein has a central role in AD and enhancing its removal improves memory loss in animal AD models. This project builds on my recent finding of regulators of a cell housekeeping system, autophagy which accelerate removal of beta amyloid in cells. This study will advance knowledge into the protective functions of the autophagy regulators in reducing AD symptoms. Findings from this work might provide the basis for developing effective anti-AD therapeutics.