Title of project or programme

Neuroscience: molecular basis and clinical applications. 1.

Principal Investigators of project/programme grant
Title Forname Surname Institution Country
Dr Luigi Institute of Biomedical Technologies, CNR, Milan Institute of Biomedical Technologies, CNR, Milan Italy
 Dr  Sale Neuroscience Institute, CNR, Pisa  Italy
 Dr  Nicola  Origlia Neuroscience Institute, CNR, Pisa  Italy
 Dr  Marta  Di Carlo Institute of Biomedical Technologies, CNR, Milan  Italy
 Dr  Nadia  Canu Insitute of cell Biology and Neurobiology, CNR, Rome  Italy
 Dr  Francesca Luisa  Conforti Insitute of Neurological Sciences, Catania  Italy
Address of institution of lead PI
Institution Enrica Strettoi, Consiglio Nazionale delle Ricerche
Street Address Neuroscience Institute
City Area della Ricerca, Via Giuseppe Moruzzi 1
Postcode 56124 Pisa
Country

Italy

Source of funding information

Consiglio Nazionale delle Ricerche

Total sum awarded (Euro)

10000000

Start date of award

01-01-2009

Total duration of award in months

60

The project/programme is most relevant to
  • Neurodegenerative disease in general
Keywords

mitochondria, environment, amyloid, signal transduction, synapse, microglia, aging, cell biology, biochemistry, pharmacology, imaging, nanoparticles

Research abstract in English

The Neuroscience Program of the Italian CNR comprises numerous lines of research headed by investigators of 10 different Institutes located all over the Country. Several laboratories carry on studies on Alzheimer’s, Parkinson’s, Huntington’s and prion disease and other disorders of the CNS. The studies are funded by the CNR, the Italian Ministry of Education, the EU and by numerous national and international foundations and charities. Methods of study range from molecular techniques to epidemiological approaches. The PIs listed above are responsible of the projects listed here (in order):

1) Cellular mechanisms of Parkinson disease: age related alterations in cellular organelles and effects on mitochondrial turnover.

2) Neurotrophic factors and Alzheimer disease: effects of environmental manipulations

3) Signalling mechanisms in Alzheimer disease: direct effects of beta-amyloid on synaptic physiology. Influence of microglial activation and ischemia on brain function in AD.

4) Molecular mechanisms of fibrillogenesis of beta amyloid peptide: biphysical and and biomolecular studies

5) Mechanisms underlying the effect of N-terminal 26-230 tau fragment on synaptic dysfunction and neurodegeneration

6) FUS (fused in sarcoma) mutations in sporadic amyotrophic lateral sclerosis: clinical and genetic analysis.

Lay summary

The Neuroscience Program of the Italian CNR comprises numerous lines of research headed by investigators of 10 different Institutes located all over the Country. Several laboratories carry on studies on Alzheimer’s, Parkinson’s, Huntington’s. ALS and prion disease and other disorders of the CNS. Methods of study range from molecular techniques to epidemiological approaches.

Types: Investments > €500k
Member States: Italy
Diseases: Neurodegenerative disease in general
Years: 2011
Database Categories: N/A
Database Tags: N/A

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