Title of project or programme
New biomarkers of motor neuron disease: role in the pathogenesis and possible therapeutic targets
Principal Investigators of project/programme grant
| Title | Forname | Surname | Institution | Country |
| Valentia | Banetto | Istituto di Ricerche Farmacologiche Mario Negri | Italy | |
Address of institution of lead PI
| Institution | Istituto di Ricerche Farmacologiche Mario Negri |
| Street Address | Via La Masa 19 |
| City | Milan |
| Postcode | 20156 |
Country
- Italy
Source of funding information
Telethon Foundation
Total sum awarded (Euro)
800000
Start date of award
13-02-2009
Total duration of award in months
60
The project/programme is most relevant to
- Motor neurone diseases
Keywords
Research abstract in English
Lay summary
Evaluation of the capability of potential biomarkers to deliver a right diagnosis of the motor neuron disease (MND) and their use as potential therapeutic targets. Particularly, a biomarker either in patients and in animal models, cyclophillin A, seems to be involved in the process that leads to death of the motor neuron. Further studies on this field could bring to the development of new and effective therapeutic approaches.