A/Pr Daniel Hatters
University of Melbourne
Pathogenic and adaptive molecular interactions with mutant huntingtin exon 1
National Health and Medical Research Council
This project aims to determine how the gene mutation that causes Huntingtons disease (HD) damages cells in the brain. The diseased gene creates a protein that is abnormally sticky, which causes it to form clumps. Our goal is to determine the components of the cell that are disrupted and damaged as clumping happens. Understanding this link will enable therapeutics to be logically designed in efforts to prevent harm to the brain, potentially before symptoms are evident.