Prof. Dr. L. van den Berg
Motor neurone diseases
More than 200,000 people worldwide are living with Amyotrophic Lateral Sclerosis (ALS), otherwise known as Motor Neuron Disease (MND) or Lou Gehrigs disease. Relatively little is known about the cause of this progressively degenerative neurological disease. There is still no treatment. The average life expectancy of ALS patients is three years. It is almost certain that the disease has a genetic basis. Project MinE is a large-scale research initiative devoted to discovering the genetic cause of ALS. The ultimate goal is to identify genes that are associated with ALS. The function of these genes may lead to disease pathways for which treatment can be developed. In this project the full DNA profiles of at least 15,000 people with ALS and 7,500 control subjects will be mapped, and comparative analyses on the resulting data will be performed.