Dr Lezanne Ooi
University of Wollongong
Protecting neurons from death: the role of CoREST
National Health and Medical Research Council
In diseases such as Alzheimers disease, Parkinsons disease and motor neuron disease, neurons degenerate and die. One contributing factor to neuronal death is inflammation. The aim of this study is to identify mechanisms that protect neurons from death. This project focuses on the role of a family of proteins (CoREST1-3) that function to reverse gene expression changes in inflammation that lead to neurodegeneration.