Dr Surabhi Bhatia
Role of Apolipoprotein D in Alzheimer's Disease and Frontotemporal Dementia
Alzheimer's disease & other dementias
alzheimer disease | frontotemporal dementia | apolipoproteins | antioxidant | amyloid beta-protein
ApoD is a highly conserved lipocalin known for its antioxidant nature and role in regulation of inflammation. Oxidative stress and neuroinflammation are known to play a critical role in dementia. This project will study the association of apoD to inflammatory and oxidative stress markers in Alzheimers disease and Frontotemporal Dementia, two major forms of dementia. It will also examine the impact of apoD on disease pathology. Hence this project will lead us to therapeutic potentials of apoD.