COHEN, ANN D.
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
USA
Role of midlife cardiovascular disease on Alzheimers Pathology and cerebrovascular reactivity in the young-old.
NIH (NIA)
2,986,186.24
15/07/2016
1
Alzheimer's disease & other dementias
Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Brain Disorders... Cardiovascular... Cerebrovascular... Clinical Research... Clinical Research - Extramural... Dementia... Heart Disease... Neurodegenerative... Neurosciences... Prevention
? DESCRIPTION (provided by applicant): The prevalence of Alzheimer’s disease (AD) is closely related to the presence of cardiovascular disease (CaVD), understanding the relationship between amyloid-beta (A?) pathology and CaVD is critically important. The overarching goal of this study is to further the understanding of the relationship between AD pathology, including A? and tau pathology and neurodegeneration, cerebrovascular reactivity and midlife CaVD. To achieve these goals, we will utilize a group non-demented participants from an existing cohort from the ongoing community-based Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, a longitudinal study that began in 2003 with a cohort of 2000 participants (43% black) between the ages of 45-75 years at study entry and has collected a wealth of longitudinal vascular measures. We hypothesize that subclinical CaVD identified in midlife is associated with increased risk for Alzheimer’s disease pathology expressed as amyloid deposition and neurodegeneration. These changes in brain structure would be associated with alterations in cognition both cross-sectionally and longitudinally. We further hypothesize that the change in cognition will result from a failure of vascular compensatory responses, marked by increases in regional cerebral blood flow and cerebrovascular reactivity.
PUBLIC HEALTH RELEVANCE: Alzheimer’s disease (AD) and cardiovascular disease (CaVD) are two of the most common disorders of aging, understanding the relationship between the pathologies of these two disorders is critically important. The goal of this study is to furthe the understanding of the relationship between AD pathology and midlife CaVD. We will utilize a group 80 participants with a wealth of existing CaVD data from the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, a longitudinal study that began in 2003 with 2000 participants (43% black) between the ages of 45-75 years. Our goal is to understand how CaVD and AD pathology interact to produce cognitive changes in the elderly.