MARIA DE FÁTIMA GOMES FERNANDES
Seaweeds from Portuguese coast: Promising therapeutics against neurodegenerative disorders
Neurodegenerative disease in general
Biodiversity within red, green and brown macroalgae offers the possibility to find a wide variety of natural compounds with high impact in food science, pharmaceutical industry and public health. In spite the Portuguese coast being home to a great diversity of seaweed, most of them are not yet studied.
The challenge proposed is the study of seaweed species found in northern Portugal coast wild or cultivated for possible application in the treatment/prevention of neurodegenerative disorders like Parkinsons (PD) and Alzheimers (AD) diseases. Different extracts/fractions and compounds from seaweeds will be characterized by chromatographic techniques and evaluated in vitro concerning their antioxidant capacity against oxygen and nitrogen reactive species, which can be in the genesis of the neurodegeneration, and their ability to inhibit a battery of enzymes related with PD and AD. The most promising ones will be further tested in neuronal cells to assess their neuroprotection properties and respective mechanisms.