Dr Nady Braidy
sirtuin single nucleotide polymorphisms in brain ageing
Alzheimer's disease & other dementias
ageing population | alzheimer disease | biomarkers | genomics | dementia
Sirtuins are histone deacetylases that have been reported to play a pivotal role in energy expenditure, mitochondrial function and pathogenesis of metabolic diseases, including neurodegenerative disorders and Alzheimers disease in particular. In this study, we will focus on the genes encoding sirtuin families, and examined the association between single nucleotide polymorphisms within genes encoding sirtuin families and functional markers for brain health.