CACIOPPO, JOHN T.
UNIVERSITY OF CHICAGO
Social Regulation of Gene Expression, Supplement
Alzheimer's disease & other dementias
Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Basic Behavioral and Social Science... Behavioral and Social Science... Biotechnology... Brain Disorders... Clinical Research... Clinical Research - Extramural... Dementia... Depression... Genetics... Mental Health... Neurodegenerative
Loneliness is strongly predictive of decrements in health and increases in depressive symptomatology in spousal caregivers of patients with Alzheimers Disease (AD) as well as controls. To what extent loneliness is associated with adverse mental and physical health in AD patients is less clear in part because the validity of self-reports can be problematic in AD patients. The finding that loneliness is relatively stable in AD patients makes it possible to treat loneliness as a trait-like measure and investigate its predictive association with adverse outcomes such as the Conserved Transcriptional Response to Adversity (CTRA) that we have identified in monocytes in longitudinal studies in humans and in a monkey model as part of our ongoing R37.