A/Pr Daniel Hatters
University of Melbourne
Surveying the physiological changes to cells in Huntington's disease
National Health and Medical Research Council
Huntington disease results from a mutation that causes the Htt protein to form abnormal toxic clusters in neurons that eventually leads to cell death. This project will develop and apply new technology to identify how the clustering process damages cells and will measure all the gene expression changes that occur during the clustering process. The project offers much potential for revealing new therapeutic targets to this incurable disease.