Title of cohort

    Swedish National Study on Aging and Care in Kungsholmen

    Acronym for cohort

    SNAC-K and SNAC-K MRI Study

    Name of Principal Investigator - Title

    Prof

    Name of Principal Investigator - First name

    Laura

    Name of Principal Investigator - Last name

    Fratiglioni

    Address of institution -Institution

    Aging Research Center (ARC), NVS, KI

    Address of institution - Street address

    Gävlegatan 16

    Address of institution - City

    Stockholm

    Address of institution - Postcode

    11330

    Country

    Sweden

    Website
    Contact email
    Funding source

    Swedish Government, VR

    Q1a. Please indicate below if your cohort includes or expects to include, incidence of the following conditions?

    Alzheimer's disease and other dementias|Neurodegenerative disease in general

    Q1b. When are studies on the above condition(s) expected to become possible?

    Already possible

    Q2a. In a single sentence what is the stated aim of the cohort?

    To increase our understanding of the aging process and to identify preventive strategies that can lead to improved health and care of the elderly. I carry out several studies within SNAC-K: e.g., (1)Vascular risk factors and mechanisms of cognitive decline in aging; (2)Dementia trends over time; (3)Functional disability (might be due to brain degeneration) trend and determinants over time

    Q2b. What distinguishes this cohort from other population cohorts?

    My research involces 2 distinguishes in this cohort: (1)epidemiological, clinical, and brain imaging data are integrated; (2)long-term follow-up that fits the need of studying health trends.

    Q3a. i) Number of publications that involve use of your cohort to date

    100

    Q3a.ii) Please give up to three examples of studies to date (Principal Investigator, Institution, Title of Study)

    Wang R, Fratiglioni L, ..., Qiu C (PI). KI, Mixed brain pathologies mediate association between vascular factors and cognitive decline. Alzheimers Dementai 2016|Liang Y, ..., Qiu (PI). KI, Biological age in the assocaition between BP and mortality. Int J Cardiol 2016|Ding M, Santoni G,..., Qiu C, ..., Fratiglioni L (PI). KI, Dementia trends in SNAC, 2010-2014 (ongoing) | Shakersain B Prudent diet may attenuate the adverse effects of Western diet on cognitive decline.| Wei-Li Xu HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study| Wei-Li Xu HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study

    Q3b. If data on research outputs are already available please paste the publication list/other data or provide a link to where these data are publicly available

    Data are avalible on request. List of publication: http://www.snac-k.se/publications/original-articles/

    Q3c. If no research has been done as yet, please explain in a few sentences what information (i.e. research findings) you expect will be gained from the population

    Q4a. Study criteria: what is the age range of participants at recruitment? Age in years From:

    60

    Q4a. Study criteria: what is the age range of participants at recruitment? To:

    103

    Q4b. Study criteria: what are the inclusion criteria?

    Eligible: community residence and institutionalized in Kungsholmen age 60+

    Q4c. Study criteria: what are the exclusion criteria?

    Language problem

    Q5. What is the size of the cohort (i.e. how many participants have enrolled)?

    1,000-5,000 participants

    Q6a. Please describe what measures are used to characterise participants

    multiple, e.g., global cognition, dementia, AD, ADL, etc. social interview, physical functioning, clinical examination, including geriatric, neurological and psychiatric assessment, cognitive assessment.

    Q6b. Are there additional measures for participants with a clinical disorder?

    CVD, diabetes, multimorbidity, etc. Proxy interview in case of cognitive impairment

    Q6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)?

    No

    If yes please specify

    Q7. What is the study design (select all that apply)?

    Prospective cohort|Longitudinal|Cross sectional survey

    Q8. Are your cases matched by

    Other health assessment

    Q9a. Does your study include a specialised subset of control participants?

    No

    Q9b. If your study includes a specialised subset of control participants please describe

    Q10a. i) Please enter the data collection start date

    01/01/2001

    Q10a. ii) Please enter the data collection end date

    Ongoing

    Q10a. iii) Is data collection for this study

    Data collection ongoing|Data analysis ongoing

    Q10b. If data collection is ongoing, are there plans to continue the cohort study beyond the current projected end date?

    Yes - funding applied for/funding awarded

    Q11. Is data collected

    Through links to medical records

    Other please specify here

    linked to inpatient registry and death certificates

    Q12. Is there a system in place to enable re-contact with patients to ask about participation in future studies?

    Yes (participants given permission to be re-contacted via PIs)

    Q13a. Please give information on the format and availability of data stored in a database (1)

    Data summarised in database

    % available

    100

    Q13a. Please give information on the format and availability of data stored in a database (2)

    No

    % available

    Q13a. Please give information on the format and availability of data stored in a database (3)

    Database on spreadsheet (e.g. excel)

    % available

    100

    Q13a. Please give information on the format and availability of data stored in a database (4)

    Database on paper

    % available

    100

    Other (please specify)

    % available

    Q13b. Please give information on the format and availability of data held as individual records (1)

    Data is held as individual records

    % available

    100

    Q13b. Please give information on the format and availability of data held as individual records (2)

    No

    % available

    Q13b. Please give information on the format and availability of data held as individual records (3)

    Data held on computer based records

    % available

    100

    Q13b. Please give information on the format and availability of data held as individual records (4)

    No

    % available

    Please specify language used

    Swedish, English

    Q14a. Is data available to other groups?

    Yes

    Q14b. If data is available to other groups what is the access policy/mechanisms for access?

    Apply to PI or co-ordinator at resource| Access independent of collaboration with PI| Local/ regional access| National access| International access| Access restricted to peer-reviewed work| Resource has own ethics approval so usually no need for separate external ethics approval

    Q15. What data sharing policy is specified as a condition of use?

    Data made publicly available after a specified time point

    Q16a. Are tissues/samples/DNA available to other groups?

    Yes

    Q16b i) If yes, please describe below:

    Living donors: blood| Living donors: blood derivatives| Living donors: DNA

    Q16b. ii) In what form are tissues/samples/DNA supplied?

    Primary Samples: Stabilised samples (frozen or fixed)| Secondary samples:(derivatives of primary samples)| Secondary samples: plasma| Secondary samples: DNA

    Q16b. iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data (Q14 above)?

    Yes

    Q17. Is information on biological characteristics available to other groups?

    Yes, for all the cohort

    Number of Patients

    % of total cohort

Types: Population Cohorts
Member States: Sweden
Diseases: Alzheimer's disease & other dementias, Neurodegenerative disease in general
Years: 2016
Database Categories: N/A
Database Tags: N/A

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