Principal Investigators


Dr Bradley Turner

Institution


University of Melbourne

Contact information of lead PI


Country


Australia

Title of project or programme


Targeting autophagy to improve protein metabolism in ALS

Source of funding information


National Health and Medical Research Council

Total sum awarded (Euro)


€ 398,117

Start date of award


01/01/2016

Total duration of award in years


3

Keywords


Research Abstract


One common feature of MND is the accumulation of protein deposits inside nerve cells which leads to their death. We have identified a potent drug which enhances autophagy, a protective process which breaks down protein deposits inside cells. We have shown that this autophagy enhancer efficiently clears protein deposits linked to MND in the Petri dish. We propose to treat MND mice with this autophagy enhancer and predict that it will slow disease signs, preserve lifespan and protect nerve cells.

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