Dr Peng Lei
Tau and APP interactions in Neurodegeneration
Alzheimer's disease & other dementias
alzheimer disease | microtubule associated protein (map) | parkinson disease | iron transport | amyloid precursor protein
Recently I co-discovered a novel relationship between the Alzheimers amyloid precursor protein and tau, both of which play a role in regulating neuronal iron levels. I predict that multiple failures in iron-regulating systems could foster a toxic iron accumulation in brain, leading to the development of neurodegenerative diseases. I hope to gain a better understanding of their mechanism of action and propose that this pathway is a target for therapeutic intervention.