University of Cambridge
Testing a new diagnostic tool for Alzheimer's disease and Dementia with Lewy Bodies
Alzheimer's Research UK
Protein aggregates are thought to play a key role in the development of Alzheimers disease but are difficult to detect since they are present at low concentrations and different structures. We have developed a method to directly detect image protein aggregates when they form a particularly damaging structure and shown that this method works in the CSF of patients allowing us to count the number and size present. This is a very exciting result and we now want to further develop this method and then do a pilot study to see if it can detect differences between patients with Alzheimers disease from normal people. This may allow the early diagnosis of the disease and monitoring of therapies.