Principal Investigators


Dr Amy Wyatt

Institution


University of Wollongong

Contact information of lead PI


Country


Australia

Title of project or programme


The effect of hypochlorite on the toxicity and clearance of the Alzheimer’s disease-associated amyloid beta peptide

Source of funding information


National Health and Medical Research Council

Total sum awarded (Euro)


€ 309,202

Start date of award


01/01/2016

Total duration of award in years


4

Keywords


Research Abstract


Alzheimer’s disease (AD) is the leading cause of dementia worldwide and a growing burden on our aging society. Recent studies support the idea that in AD a deleterious relationship exists between inflammation in the brain and the accumulation of amyloid beta (Aß), a peptide with toxic properties. This proposal aims to examine the details of this relationship with a focus on the toxicity and clearance of Aß when it is modified by hypochlortie, a chemical that is generated during inflammation.

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