Name of resource

The Harwell Frozen embryo and sperm archive (FESA)

Name of Principal Investigator
Title Dr
First name Martin
Last name Fray
Address of institution where award is held
Institution MRC Harwell
Street Address Harwell Science and Innovation Campus
City Oxford
Postcode OX11 0RD
Country
  • United Kingdom
  • Website

    http://www.har.mrc.ac.uk/

    Contact email

    m.fray@har.mrc.ac.uk

    Summary

    The MRC’s frozen embryo and sperm archive holds a collection of mouse models of human disease that are distributed to the wider scientific community. We also hold some mouse models that have been frozen for our own researchers that are not available to the community.

    1a. The resource holds animal models relevant to the study of the following neurodegenerative diseases
  • Motor neurone diseases
  • Prion disease
  • Huntington’s disease
  • Neurodegenerative disease in general
  • Parkinson’s disease
  • Spinocerebellar ataxia (SCA)
  • Spinal muscular atrophy (SMA)
  • 1b. The resource holds:
  • Animals
  • Frozen embryos
  • Frozen sperm
  • 2a. The resource acts as a centre for access and distribution to external groups (who are not the PIs of the resource)
    2b. Procedures and rules for access
  • Access independent of collaboration with PI
  • Local/ regional access
  • National access
  • International access
  • Access to industry
  • Charge for retrieval
  • 3a. Does the resource develop animal models for external groups

    1

    3b. Types of models provided
  • Not applicable
  • 4a This activity is supported as:
  • Independent of collaboration
  • 4b. The supplied material deposited in a central repository

    2

    5a Disease models available
    Disease Species Available to external user (Y/N) Full phenotypic character (Y/N or partial) Phenotypes Genotypes or other subtypes
    HD Mouse N Partial Short life span/tremors Hets
    Prion Mouse Y Y Suceptibility to disease Hets/Homs
    SMA Mouse Y Partial Neuropathology Homs
    PD Mouse Y Partial Olfactory memory and motor control Het
    MND Mouse Y Y Mice show dystrophic changes in mucscle histopathology Hets/Homs
    5b. Other models/phenotypes available through the resource relevant to neurodegenerative conditions
    No. of models Available to external users Full phenotypic characterisation available (Y/N or partial) Nature of phenotype
    Low grip strength 3 Y Partial
    2 Y Partial Memory deficit
    2 Y Partial Muscle tremors
    Numerous Y Partial Various phenotypes
    6. European or international consortia or networks to which the resource is linked
    Jackson Laboratories, USAInternational mouse knockout consortium
    European Mutant Mouse Archive
    International Mouse Knockout Consortium
    7a. Maintenance of the resource is dependent on continued funding

    1

    7b. End date of current funding period

    N/A

    7c. Expected lifespan of the resource (in years)

    1000

    7d. Other plans affecting future use

    FESA is a core funded MRC resource but it is also supported in part by the funds we receive from the EU through our membership of the EMMA consortium. The current EMMA grant will come to an end Dec 2012.

    Types: Experimental Models
    Member States: United Kingdom
    Diseases: Huntington's disease, Motor neurone diseases, Neurodegenerative disease in general, Parkinson's disease & PD-related disorders, Prion disease, Spinal muscular atrophy (SMA), Spinocerebellar ataxia (SCA)
    Years: 2011
    Database Categories: N/A
    Database Tags: N/A

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