The Harwell Frozen embryo and sperm archive (FESA)
|Street Address||Harwell Science and Innovation Campus|
The MRC’s frozen embryo and sperm archive holds a collection of mouse models of human disease that are distributed to the wider scientific community. We also hold some mouse models that have been frozen for our own researchers that are not available to the community.
|Disease||Species||Available to external user (Y/N)||Full phenotypic character (Y/N or partial)||Phenotypes||Genotypes or other subtypes|
|HD||Mouse||N||Partial||Short life span/tremors||Hets|
|Prion||Mouse||Y||Y||Suceptibility to disease||Hets/Homs|
|PD||Mouse||Y||Partial||Olfactory memory and motor control||Het|
|MND||Mouse||Y||Y||Mice show dystrophic changes in mucscle histopathology||Hets/Homs|
|No. of models||Available to external users||Full phenotypic characterisation available (Y/N or partial)||Nature of phenotype|
|Low grip strength||3||Y||Partial|
|Jackson Laboratories, USAInternational mouse knockout consortium|
|European Mutant Mouse Archive|
|International Mouse Knockout Consortium|
FESA is a core funded MRC resource but it is also supported in part by the funds we receive from the EU through our membership of the EMMA consortium. The current EMMA grant will come to an end Dec 2012.