Dr Emma Burrows
The missing link: mGluR5 as a therapeutic target for cognitive decline in dementia
Alzheimer's disease & other dementias
dementia-related decline in memory | alzheimer disease | mouse models | memory impairment | pharmacology
Cognitive decline is a core feature of Alzheimers Disease (AD), yet there is no cure or treatment. Recent evidence suggests that a protein called mGluR5 could cause brain cells to lose function, leading to memory loss. This project will investigate whether disrupting mGluR5 function can improve cognition in mice with genetic AD. Memory will be assessed in mice using innovative touchscreen tests that closely mimic the tests used in humans.