Name of Fellow

    Prof Jernej Ule



    Wellcome Trust

    Contact information of fellow


    United Kingdom

    Title of project/programme

    The role of 3' UTR variation in the molecular pathogenesis of motor neuron disease.

    Source of funding information

    Wellcome Trust

    Total sum awarded (Euro)

    € 1,874,372

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Neurodegenerative disease in general


    Amyotroph | Motor Neuron

    Research Abstract

    3′ untranslated regions (3′ UTRs) play critical roles in the control of mRNA translation and stability by presenting sequence motifs and secondary structural elements that mediate interactions between the mRNA and other factors such as proteins or miRNAs. Recent studies have demonstrated that human genetic variations in UTRs impact upon gene expression to a similar degree to variations in promoter sequences. We hypothesise that 3′ UTR sequence variation disrupts mRNA stability and the control of transcription, which can contribute to the pathogenesis of diseases such as cancer or neurodegeneration. We will use a combination of genetic and biochemical investigations in differentiated human motor neurones with computational modelling to study the impact of alternative 3′ UTRs on health and disease.

Types: Fellowships
Member States: United Kingdom
Diseases: Neurodegenerative disease in general
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF