A/Pr Giuseppe Verdile
Curtin University of Technology
The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease
National Health and Medical Research Council
The Presenilin and APP proteins are centrally important in inherited, early onset Alzheimer’s disease. We have discovered that a shortened form of Presenilin protein, “PS2V”, appears to increase specifically the rate at which the APP protein is cleaved to produce the “Amyloid beta” protein fragment that is found in Alzheimer’s disease brains. This occurs when brain cells are under oxidative stress. Understanding this process will facilitate development of appropriate therapeutic strategies for the disease.