Name of Fellow


Dr Sam Buckberry

Institution


Funder


NHMRC

Contact information of fellow


Country


Australia

Title of project/programme


The role of the neuronal epigenome in natural brain ageing and the progression of Alzheimer’s disease

Source of funding information


NHMRC

Total sum awarded (Euro)


€ 396,633

Start date of award


01/01/16

Total duration of award in years


4.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


methylation | epigenetics | neurogenetics | neurodegenerative disorders | genomics

Research Abstract


Most cases of Alzheimer’s disease are sporadic or late onset, with only ~5% of cases being familial, suggesting a potential role for epigenetics. This project aims to profile the human brain epigenome throughout normal ageing and in Alzheimer’s disease so we can determine how disturbed epigenetic states may affect brain function. This research will provide new insights into the role of the epigenome in Alzheimer’s disease, enabling crucial advances in understanding its origins.

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