The Vallecas Project – Early detection of Alzheimer’s Disease
|First name||Jose L.|
|Institution||Research Unit, Alzheimer Center Reina Sofia Foundation|
|Street Address||Calle de Valderrebollo, 5|
Reina Sofia Foundation
Alzheimer Disease Association (AFAL)
- Alzheimer’s disease and other dementias
To obtain an algorithm of probability (based on historical, clinical, neuroimaging, and biological data) for calculation of the dementia/AD risk in a 5-year horizon. Pilot study done. Launching: June 2011.
To identify, in population 70-85 y., the individuals in risk for dementia in few years, based on clinical data, MRI, and blood, using data mining. Aimed at finding a probability, not a marker.
This integrator study will provide socio-demographic and clinical data that combined with biological data from blood and MRI will allow to calculate the risk for development of dementia in a few years span. For clinical trials with disease modifiers, this population will be essential (and preferential for treatment).
|Age in years from:||70|
|To (‘until death’ if applicable):||85|
Population 70 to 85 years old, without dementia ot other impairment of mental function interfering with daily life. Subjective memory complaints and mild cognitive impairment are suitable for inclusion.
Dementia (any degree) at baseline, or other disorder of mental functions interfering with assessments. Existence of a severe disease impeding long-term follow-up.
1,000 – 5,000 participants
MMSE, Pfeffer’s FAQ, Visuospatial tests, CDR <1
Set Test, Buschke’s Verbal Learning test, Symbol-digit test, Apathy inventory, motor evaluation.
MRI 3T – Volumetry,
Blood- APOE, susceptiblity genes, biochemical determinations
- Prospective cohort
- Cognitive function
- At the planning stage
- Only through the study
Yes (participants have given permission to be re-contacted via the PIs to ask if they would participate in further studies)
|Data summarised in database|
|Database is web-based|
|Database on spreadsheet||Yes|
|Database is on paper|
|Data held as individual records|
|Data is web-based|
|Data held on computer based records||Yes|
|Data held on cards|
No policy exists
- Living donors:blood
- Living donors: blood derivatives
- Living donors: DNA
- Post-mortem donors: brain
- Primary samples: Supplied fresh
- Primary Samples: Stabilised samples (frozen or fixed)
- Secondary samples: derivatives of primary samples
- Secondary samples: plasma
- Secondary samples: DNA
- Secondary samples: RNA
- Secondary samples: protein extracts
- Secondary samples: cell lines derived from primary samples