Title of the cohort

The West of Scotland Twenty 07 Study

Acronym for cohort
Name of Principal Investigator
Title Ms
First name  Michaela
Last name Benzeval
Address of institution where award is held
Institution MRC Social and Public Health Sciences Unit
Street Address 4 Lilybank Gardens
City GLASGOW
Postcode G12 8RZ
Country

United Kingdom

Website

http://2007study.sphsu.mrc.ac.uk/

Contact email

m.hannah@sphsu.mrc.ac.uk

Funding source

Medical Reseach Council

1. The cohort includes, or expects to include, incidence of the following conditions
  • Neurodegenerative disease in general
When studies on the above condition(s) are expected to become possible

Already possible

2a. Stated aim of the cohort

The Twenty-07 Study was set up in 1986 in order to investigate the reasons for differences in health by socio-economic circumstances, gender, area of residence, age, ethnic group, and family type.

2b. Features distinguishing this cohort from other population cohorts

The study consists of three cohorts born twenty years apart and each followed up for twenty years.

3a. i) Number of publications that involve use of cohort to date
0
3a. ii) Up to three examples of studies to date (PI, Institution, Title of Study)
3b. Publication list/link to where data or publications are accessible (if available)

http://2007study.sphsu.mrc.ac.uk/publications.html

3c. Information (i.e. research findings) expected to be gained from the population cohort
4a. Study criteria: age range of participants at recruitment
Age in years from: 15
To (‘until death’ if applicable): 55
4b. Study criteria: inclusion criteria

Living in the study area, in the community, being one of the appropriate ages, and being selected via the two stage random sampling process. ee Benzeval M, Der G, Ellaway A, Hunt K, Sweeting H, West P, Macintyre S. Cohort Profile: West of Scotland 20-07 study: health in the community. International Journal of Epidemiology 2009; 38:1215-23.

4c. Study criteria: exclusion criteria

Not living in the study area, not in the community, not being one of the appropriate ages, and not being randomly selected. ee Benzeval M, Der G, Ellaway A, Hunt K, Sweeting H, West P, Macintyre S. Cohort Profile: West of Scotland 20-07 study: health in the community. International Journal of Epidemiology 2009; 38:1215-23. At most waves, respondents with (say) severe dementia and those living in institutions would not have been interviewed. At the final wave in 2007/2008, some respondents with dementia were given a shortened or proxy interview and some in institutions were interviewed.

5. Size of the cohort (i.e. number of participants enrolled)

1,000 – 5,000 participants

6a. Measures used to characterise participants

Self-reported health
General well-being
Symptoms
Chronic conditions
Disabilities
Vision
Hearing
Mental health
Use of health care services
Medications
Physical health measures
Height (standing and sitting)
Weight
Waist
Hips
Blood pressure
Respiratory function
Grip strength
Bioimpedance
BP reactivity (wave 3 only)
Biological samples
Secretory Immunglobulin A (wave 3 only)
Blood samples (wave 5 only)
DNA (wave 5 only)
Cognition
AH4 (waves 1,4,5 only)
Reaction times
Life circumstances
Family formation
Household composition
Housing tenure and conditions
Ownership of household goods
Domestic labour & caring responsibilities
Family health
Employment status
Occupation and work environment
Income
Family networks
Social support
Life events
Behaviours
Diet
Exercise
Smoking
Alcohol and illegal drug use
Sexual behaviour and contraceptive use
Preventative health care use
Illness behaviour
Social participation
Leisure activities
Criminal activities
Beliefs, attitudes and values
Concepts of health
Beliefs about illness
Health knowledge
Self esteem
Mastery
Religious beliefs
Worries
Beliefs about gender, age and marital roles
Life satisfaction
Opinions

See Benzeval M, Der G, Ellaway A, Hunt K, Sweeting H, West P, Macintyre S. Cohort Profile: West of Scotland 20-07 study: health in the community. International Journal of Epidemiology 2009; 38:1215-23.

6b. Additional measures for participants with a clinical disorder

No, although details such as severity and medications were asked of any medical conditions reported.

6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)

At each wave of the study there were questions on medical conditions. Also, respondents are flagged for mortality with the NHSCR so we have cause of death for those who have died.

7. Study design
  • Prospective cohort
8. Cases matched by
  • Other health assessment (specify) / N/A
  • not matched
9a. Does the study include a specialised subset of control participants

No

9b. If yes, description of specialised subset of control participants
10a. i) Data collection start date

01-01-1987

10a. ii) Data collection end date

31-12-2008

10a iii) Data collection for this study is

Data analysis ongoing

10b. Plans to continue the cohort study beyond the current projected end date
  • No
11. Data collected
  • Through links to other records or registers (such as dental records, police records etc). Please specify
  • links to NHSCR for death certificates
12. System in place to enable re-contact with patients for future studies

Yes (participants have given permission to be re-contacted via the PIs to ask if they would participate in further studies)

13a. Format and availability of data stored in a database
Yes/No % available
Data summarised in database  yes  100%
Database is web-based
Database on spreadsheet
Database is on paper
Other (specify)
Language used:

English

13b. Format and availability of data held as individual records
Yes/No % available
Data held as individual records  yes  100%
Data is web-based
Data held on computer based records
Data held on cards
Other (specify)
Language used:

English

14a. Are data available to other groups

Yes

14b. Access policy/mechanisms for access if data are available to other groups
  • Apply to PI or co-ordinator at resource
  • Access through collaboration with PI only
  • Access Committee mechanism
  • Local/ regional access
  • National access
  • Access restricted to peer-reviewed work
  • Other criteria (please specify) See http://2007study.sphsu.mrc.ac.uk/access-to-information-collected-by-the-twenty-07-study.html
15. Data sharing policy specified as a condition of use

Data to be made publicly available immediately

16a. Are tissues/samples/DNA available to other groups

Yes

16b. i) Description of available tissues/samples/DNA
  • Living donors:blood
  • Living donors: DNA
16b. ii) Form available tissues/samples/DNA are supplied in
  • Secondary samples: plasma
  • Secondary samples: DNA
  • Other, please specify
  • Secondary samples: serum
16b. iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data

No

17. Is information on biological characteristics available to other groups
  • If available for a subset please specify number of patients and % of total cohort
  • 2310 approx 50%

Types: Population Cohorts
Member States: United Kingdom
Diseases: Neurodegenerative disease in general
Years: N/A
Database Categories: N/A
Database Tags: N/A

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