Title of project or programme
Title of PI Stem and progenitor cells of the postnatal CNS
Principal Investigators of project/programme grant
Title Forname Surname Institution Country
Professor William Richardson University College London UK
Address of institution of lead PI
Institution University College London
Street Address Wolfson Institute for Biomedical Research, The Cruciform Building, Gower Street
City London
Postcode WC1E 6BT
Country
  • United Kingdom
Breadcrumb to current pageMain content Search our Database Major Programmes or research grants Title of project or programme Stem and progenitor cells of the postnatal CNS Principal Investigators of project/programme grant Title Forname Surname Institution Country PI 1 Professor William Richardson University College London UK PI 2 PI 3 PI 4 PI 5 PI 6 Address of institution of lead PI Institution University College London Street Address Wolfson Institute for Biomedical Research, The Cruciform Building, Gower Street City London Postcode WC1E 6BT Country United Kingdom Source of funding information

Medical Research Council

Total sum awarded (Euro)

2273933.41

Start date of award

16-01-2009

Total duration of award in months

60

The project/programme is most relevant to
  • Motor neurone diseases
Keywords
Research abstract in English

We showed recently that the adult forebrain subventricular zone (SVZ) contains a mixture of stem cells that have spatially diverse origins in the embryonic telencephalon and different neurogenic properties in the adult. We shall use genetically manipulated mice to dissect the roles of these different SVZ stem cell sub-populations in adult olfactory neurogenesis and olfactory behaviour, and their possibly distinct regenerative responses to damage. There are also stem cells in the adult spinal cord ependymal zone (EZ) surrounding the central canal. By analogy with the SVZ, the EZ might be expected to inherit the spatially patterned cell fate restrictions of the embryonic neuroepithelium. We will test this by mapping the embryonic origins of the EZ and asking whether embryonic ancestry predicts adult stem cell response to degenerative disease (a genetic model of motor neuron disease), demyelination or physical injury. Finally, we shall examine the role of NG2 cells (an abundant and ubiquitous population of progenitor cells in the adult CNS) in adult gliogenesis and cortical neurogenesis, testing the ideas that de novo myelination of previously naked axons contributes to neural plasticity and that adult-born cortical projection neurons likewise have a significant functional role.

Lay summary
In which category does this research fall?
  • Basic research

Types: Investments > €500k
Member States: United Kingdom
Diseases: Motor neurone diseases
Years: 2011
Database Categories: N/A
Database Tags: N/A

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