Prof. Dr. E.J.A. Scherder
VU University Medical Center
Train the sedentary brain: move smart to reduce the risk of dementia
Alzheimer's disease & other dementias
Physical inactivity (PIA) is a critical risk factor for developing dementia. Our multidisciplinary experts consortium will determine how specific exercise protocols can counter the negative effects of PIA on dementia progression. Primary targets are the APOEe4 carriers, people most at risk to develop dementia. The hypothesis is that physical activity (PA) slows cognitive decline and dementia progression. We will test this hypothesis by generating insights into: a) how PIA impairs cognitive functions, b) how PIA interacts with APOEe4 expression, c) which PA protocols are most promising to slow cognitive decline and dementia progression. Experts monitor the implementation aspects of the PA protocols at all stages. We will address this challenging hypothesis using novel approaches that includes preclinical mouse models and diverse clinical PA protocols. A multitude of stakeholders will benefit from the translation of scientific knowledge to slow dementia progression.