Name of ResourceTransgenic HD Minipig (TgHD, PIGMOD Center)
Name of Principal Investigator - Title
Name of Principal Investigator - First name
Name of Principal Investigator - Last name
Address of institution -InstitutionInstitute of Animal Physiology and Genetics-PIGMOD Center
Address of institution - Street address
Address of institution - City
Address of institution - Postcode
SummaryAt present, we are probably the only facility to be breeding TgHD minipigs. We have four generations, around 180 animals. The animals are beiing studied for phenotype development, and also first preclinical testing with a pharmaceutical company Uniqure is beeing done. We hope to attract more companies for testing their therapeutic treatment on this unique large animal model for Huntingon's disease. Funded by CHDI, Czech-Norwegian Research Programme 7F14308, National Programme of Sustainibility LO1609
Q1a. Please indicate below if your cohort includes or expects to include, incidence of the following conditions? (1)
Q1b. Does your resource holdAnimals| Other - animal-derived embryonic neural stem cells
Q2a. Does the resource act as a centre for access and distribution to external groups (who are not the Principal Investigators (PI) for the resource)?
Q2b. If Yes, what procedures and rules apply for access?Apply to PI or co-ordinator at resource|Access through collaboration with PI only|International access
Q3a. Does your resource develop experimental models (animal/cell) for external groups?
Q3b. If YES and your resource is related to an ANIMAL model, what types of models are provided?
Q3c. If YES and your resource is related to a CELL model, what types of models are provided?Other - TgHD and control animal derived
Q4a. Is this activity supported as:
Q4b. Do you deposit what you supply in any kind of central repository?
Available to external user
Full phenotypic characterMale fertility failure at 13 months, At two years: fragmentation of Htt in brain, and testes, neuroinflamation, decrease in total creatine in thalamus, At two years: fragmentation of Htt in brain, and testes, neuroinflamation, decrease in total creatine in thalamus, At four years: mitochondria impairment in heart and muscles, At five years: starting biohavioral and motoric problems based on three available pairs at this age
Please indicate the phenotypesFour generations of minipigs with N-terminal part of human mutated (128Q,523AA)HTT expressed under the human promoter at chromosome 1 (1q24-q25) of porcine DNA and their wild type sibling.
List of genotypes or other subtypes
Q5b. Cognitive function, No of models
Q5b. Cognitive function, Available to external users
Q5b. Cognitive function, Full phenotypic characterisation
Q5b. Cognitive function, Nature of phenotype
Q5b. Motor function, No of models
Q5b. Motor function, Available to external users
Q5b. Motor function, Full phenotypic characterisation
Q5b. Motor function, Nature of phenotype
Q5b. Physiological function, no of models
Q5b. Physiological function, Available to external users
Q5b. Physiological function, Full phenotypic characterisation
Q5b. Physiological function, Nature of phenotype
Q5b. Other function (please specify), no of models
Please specify other function
Q5b. Other function (please specify), Available to external users
Q5b. Other function (please specify), Full phenotypic characterisation
Q5b. Other function (please specify), Nature of phenotype
Q6. Please indicate if your resource is already linked into European or international consortia or networks?
Q7a. Is maintenance of this resource dependent on continued funding?
Q7b. If yes, when does the current funding period end?
Q7c. What is the expected lifespan of the resource (in years)?
Q7d. Are there other plans affecting future use that it may be useful to know?
Types: Experimental Models
Member States: Czech Republic
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A
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