Principal Investigators


Professor S M Bird

Institution


MRC Biostatistics Unit

Contact information of lead PI


Country


United Kingdom

Title of project or programme


Transmissible disease epidemiology & statistical science in public health, criminal justice & performance monitoring

Source of funding information


MRC

Total sum awarded (Euro)


€ 1,381,028

Start date of award


01/04/2011

Total duration of award in years


5.0

The project/programme is most relevant to:


Prion disease

Keywords


Research Abstract


Statistical science is about well-designed data capture and disciplined study protocols as well as analytical techniques. We apply, and develop, statistical science at the interface of public health and other jurisdictions. In particular, we focus on transmissible diseases which transit other jurisdictions (BSE and vCJD, HIV and Hepatitis C, pandemic flu, and injecting drug use), on ethical database linkages, and cost-efficient formal designs (including randomisation) to test model assumptions and find out whether criminal justice or public health interventions work. Naively set targets often conceal a lack of basic understanding of how to improve performance. They delay research, and waste or divert resources, especially if institutional compliance is statistically mis-judged. Because the criminal justice system is enriched for clients who have a multiplicity of health problems, such as addictions, mental health and blood-borne viruses, criminal justice settings are a cost-efficient location for trialling and implementing interventions that ameliorate the (public) health of often marginalised communities. We work in 6 main areas, as follows: UK surveillance of secondary vCJD, including provision for autopsYes surveillance, and database linkage studies to elucidate operative risks. Epidemiological mapping of avian flu and human H5NI outbreaks, together with design for, and trialling of, data acquisition (daily matrix of personal meetings), programs and analysis to test feasible social distancing strategies for limiting human flu. Efficient recall by diagnosed flu cases of their recent past contacts is needed if we are to estimate transmission rates robustly. Statistical exploitation of Scotlands key data-sources on heterosexually transmitted and drug-resistant HIV is also of interest. Testing, monitoring, and updating of our published projections on late liver sequelae of Scotlands injector-related Hepatitis C epidemic, with particular attention to debiased estimation of prognostic influences (notably: heavYes alcohol consumption), and their prevalence. Database linkage designs to quantify demographic influences on drugs-related mortality; 12-week risk of suicide by recently-released prisoners; and quantification of transition rates (and time-dependent influences thereon) between healthcare settings, drug treatment and prison. Designs for evaluating criminal justice or public health interventions in criminal justice settings, with specific attention to performance monitoring, value-for-moneYes, and cost-effectiveness. key words: Statistical monitoring, transmission studies, database linkage, policy designs, vCJD, influenza A, blood-borne viruses, drugs-related deaths, criminal justice

Lay Summary


Statistical science can solve problems posed by transmissible diseases. Can you name whom you met 2 days ago? your answer could save lives in pandemic flu. The human form of mad cow disease is vCJD. It threatens our blood supply and operating theatres because there is no blood test and imperfect decontamination of surgical instruments. yet, we need to estimate how many of us, by age-group, are carriers of vCJD. And what the risk is to others of operations on us. AutopsYes studies hold important answers, but require public trust. Sexual transmission of HIV disease is a concern. Some infectors have been put in prison for reckless sexual transmission of HIV. Many more do so with impunity. Criminalisation has not solved HIVs sexual transmission. Better public health science, using molecular techniques and contacting partners of those recently HIV infected, can. Nine out of 10 people infected with hepatitis C have injected drugs, most have been in prison, and some drink heavily, which hastens cirrhosis. Criminal settings are a good location for testing interventions to improve the health of marginalised communities. We use record linkage to study transitions, some fatal, between health and criminal settings. Naive targets delay proper research on how to reduce re-offending and drugs-related deaths, and divert resources if institutions are wrongly judged as non-compliant.

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