General Information

Mouse: C57BL/6 x 129/SvEvBrd

Mice in which exon 2 and exons 3-5 of the PINK1 gene have been replaced by IRES-lacZ/MC1neo using homologous recombination.

Corresponding human genotype: Autosomal recessive mutation in the PINK1 gene causing a loss-of-function of the protein and leading to early-onset Parkinson’s disease (PARK6).

Mutated gene: PINK1

References: Wood-Kaczmar 2008, Bishop 2010 

Loss of dopaminergic neurons

  • No apparent loss of TH-positive neurons is observed

Dopamine Homeostasis

  • Not reported

Inclusions

  • Not reported

Motor Behaviours

  • Not reported

Response to dopaminergic treatment

  • Not reported

Non motor Behaviours

  • Not reported

Electrophysiology

  • 3-4 months: dopamine neurons (brain slices) show irregularities in firing rates but no differences in action potential firing rates. These changes are linked to reduced SK channel function. These changes are specific for dopaminergic neurons and are not observed in GABA neurons.
    SN dopamine neurons display hyperexcitability (in vivo electrophysiology)

Neuroinflammation

  • Not reported

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